Intellectual capital has become the core carrier of technological innovation competitiveness. The Paper is based on basic model of technological innovation inputs and outputs, to clarify the drain of international intellectual resources of the impact mechanism on technological innovation. It tests showed that the drain of international intellectual resources will take a significant positive effect on the technological innovation of "bulk power", compared to remittances effects (RE), education incentive effects (EIE) and network effects (NE) to technological innovation is more significant. Further, the "threshold characteristics" inspection, it shows that the level of economic development and the level of R & D investment have a U-shaped relationship with technological innovation, human capital and technology gap take inverted U-shaped relationship. To this end, constructing the appropriate path and arrangements to promote the effectiveness of the intellectual resources drain , in order to achieve technological innovation and progress of the developing countries.