The network and knowledge have become the key to improving the synergistic innovative capability (SIC), and this paper explores the differences between networks of different attributes and enhancement of SIC by knowledge. Based on the systematic literature review, a theoretical model is put forward involving the relationships among synergistic innovative network (SIN)，knowledge integration (KI) and SIC. Using the multiple regression and structural equation and the mediation effect testing method, it tests empirically the theory model. The empirical findings based on 198 Technology-based SMES from Zhejiang province suggest that heterogeneous network and homogenous network can enhance SIC for SMEs, but the effect of the former is significantly greater than the latter. Heterogeneous knowledge integration plays a full mediating role between heterogeneous networks and SIC. Moreover, homogeneous knowledge integration plays a partial mediating role between homogeneous network and SIC.