A crucial debate between Romer(1990) and Jones(1995) is centered on whether there is scale-effect or not in knowledge production process. This paper estimates the scale-effect of the knowledge production of innovation economy sector of NHIDZ by using panel data method. We find that the stock of knowledge and human capital play significant role in the knowledge production process, and the output elasticity with respect to the stock of knowledge is around 0.89-0.97, the output elasticity with respect to human capital is around 0.52-0.64.The sum of the output elasticity of the stock of knowledge and human capital is significantly greater than 1, indicating that the knowledge production of innovation economy sector of NHIDZ does have scale-effect to the existing stock of knowledge and human capital，and the facts support the Romer-type knowledge production function. This finding can be useful for the making of innovation policy.