Based on the special environment of ChiNext market, this paper from two dimensions of patens output efficiency and quantity to study the influence of internationalization strategy for indigenous technical innovation of Chinese entrepreneurial companies. We find that innovation and internationalization is becoming an important strategic behavior for the Chinese entrepreneurial companies. Although Chinese entrepreneurial companies young, but they already have a considerable international competitiveness. Moreover, internationalization strategy have significant efficiency improvement effects on the patents output. The higher degree of internationalization, the more output of patents. The Chinese entrepreneurial companies, implemented internationalization strategy, have more patent output quantity. The conclusions of the paper help us well understanding the internationalization strategy and indigenous innovation of Chinese entrepreneurial companies, and put forward some valuable suggestions and decision-making basis for Chinese regulator to making international development policy for emerging industries of strategic importance, and deepening the development of indigenous innovation.