Scientific and technological entrepreneurship is a sustainable path of agricultural development. The initial venture capital is an important guarantee for farmers' scientific and technological innovation. Based on the previous research and questionnaires of Chongqing and Sichuan province’s science and technology entrepreneurial farmers, we propose a model about the influence of science and technology entrepreneurial willingness of farmers. The results show that education level, personal endowment, contacts, work experience, number of contacting with friends and relatives per month, initial social capital, and financial service conditions have significant impacts on framers’ science and technology entrepreneurship. But we do not find the same significant result on the factors such as sex, age, marital status, frequency of contact relatives monthly, the cost of scientific and technological achievements in the initial start-up capital of farmers and venture capital investment.