In the 10th anniversary of open innovation, this paper reveals the future development of open innovation from the perspective of big data. Firstly, by analyzing the characteristics of Big Data from the dynamic perspective, this paper concludes the feature of “4C”. Based on this, the paper exposes the challenges of big data to open innovation from the angle of knowledge, market, management and customer. And then this paper dissects the impact of big data on open innovation from three perspectives, which include constitution of open innovation, innovation space and business model. By summarizing the future development of open innovation from five aspects, this paper gets the following five conclusions: (1) paying more attention to strategic benefits, (2) spreading gradually to non-stakeholders, (3) emphasizing stably on the abilities based on data, (4) evolving slowly into couple-model, and (5) becoming popular. Finally, this paper gives some advice from three aspects, including methods, procedures and level, which is constructive to exploring open innovation deeply in the era of big data.