Abstract：There exists much research that suggested that strategic human resource management (SHRM) can improve firm performance and build competitive advantage. Nonetheless, it is not yet known whether and how SHRM influences product innovation performance. This study was conducted among 151 chief executive officers and human resource managers from Chinese manufacturing firms to test the impact of SHRM on product innovation performance. The results show that SHRM has positive influence on product innovation performance. Corporate entrepreneurship mediates the relationship above. Moreover, entrepreneurial orientation moderates the relationship between SHRM and corporate entrepreneurship, and corporate entrepreneurship also mediates the moderated relationship among SHRM, entrepreneurial orientation, and product innovation performance. This paper enriches the studies that focus on the SHRM-product innovation performance linkage. The findings of this paper also have implications for the improvement of product innovation performance.