Abstract: The relationship model of online enterprise-customer interaction, knowledge co-creation and new product development performance is constructed, and the structural equation model analysis is carried out on the questionnaire survey data of the new product development sample in Zhejiang province. This paper obtained the key findings: information oriented interaction and task oriented interaction both have significantly positive effect on extroverted knowledge co-creation and introverted knowledge co-creation ; Relationship oriented interaction has a significantly positive effect on extroverted knowledge co-creation; Extroverted knowledge co-creation and introverted knowledge co-creation both have significantly positive effect on new product development performance.