Abstract: Technological innovation and technological change are closely interrelated to the economic growth and economic development; today it becomes the central issue of management and economic investigation both in theory and practice. As the most hardcore resource of technological innovation, knowledge is attached great importance to the technological innovation investigation. The latest progress of current technological innovation investigation is expounded based on the view of knowledge evolution; the existing achievements are summarized and wmmented. Furthermore, the investigating direction related to technological innovation is elementarily analyzed in the view of knowledge evolution, it is indicated that the main effortful directions of technological innovation investigation are searching for a uniform investigation paradigm and an appropriate analysis instrument and establishing a rigorous system of conceptionlogic. In addition, developing a calculative experimentation theory suitable for the technological innovation demonstration investigation is another field requiring precedence efforts.