Abstract: According to the scientific developmentview putting people first and aiming at the comprehensive, coordinattive and sustainable development, the comprehensive evaluation system of science and technology is established through widely choosing and filtrating targets, which is fit for 14 province districts. On the basis of the evaluating rules, such as science and technology input/output, impact of science and technology on the economy and society and so on, 14 province districts are classified as three categories-good, medium, and bad by the clustering method and the empirical research conducted on them puts the feasible advice forward using the established science and technology evaluation model based on the super-efficiency DEA. Its features and innovations are as follows: Firstly, it puts together the provinces whose science and technology strengths are close by the clustering method and the DEA is used to evaluate each category so that the phenomenon of anamorphic evaluation results for different kinds of evaluating objects will not happen. Secondly, it reveals the input redundancy and the output deficiency of science and technology for the province districts which don’t reach the optimal efficiency by calculating the input redundancy and the output deficiency. In the light of these results, the feasible advice is provided. Thirdly, according to the impact principle of science and technology on economy, the coordinative and sustainable development are taken into account and a target system of coordinative and sustainable development reflecting the connotation of scinetific development view is set up.