Abstract: In recent years, the structural transformation of the manufacturing industry in coastal developed areas of China has become the hot spot of the theory and practice. One analytical framework is established for the study in restructure of regional manufacturing industry, and the change of the magnitude and direction from 1990 to 2006 is measured in Zhejiang province. The empirical results show that from 1990 to 2006, the structure of the manufacturing industry in Zhejiang province underwent great adjustment process in a large scale, and gradually transform into the field with high artificiality and high technicalization, but it still remains in the low-end of value chain. The degree of industry ecologicalization is not high. In the end, the inspirations to the restructuring of regional manufacturing industry in Zhejiang province from empirical results have been suggested.