The impact of IT capability and information sharing on R&D collaboration is examined, a conceptual model of the relationships between IT capability, the level of information sharing and the direct output, effect and long-term utility of R&D collaboration is provided, the corresponding hypotheses had been put forward on the basis of theoretic analysis. Questionnaire investigation was used in the phase of empirical research. SPSS and AMOS were applied as a date analysis tool and the Structural Equation Model (SEM) was set up. The result has demonstrated that the impact of IT capability on the direct output, the effect and the long-term utility of R&D collaboration appears an increasing tendency. But the impact of information sharing on the three dimensions of R&D collaboration appears a descending tendency, and IT capability also has a positive effect on the information sharing.