The reasonable profit distribution is essential for esteblishing the cooperative innovation community between universities and enterprises, and great importance to accomplish the innovation. Based on the profit distribution mix-mode and the correlative game theory, the profit distribution model of cooperative innovation between universities and enterprises is built up, and the optimum agreement for the interest distribution is explored. Considering the maneuverability and the application value of the model, the estimating method for related parameters is provided. . 8 Refs In Chinese   Science Research Management2008,29(1).8—13