Since 1987, reform and opening up, Zhejiang has stepped into a great province of manufacturing industry. Here, every sector of Zhejiang manufacturing industry was analyzed and compared from the quantitative point using the input-output method. By means of the influence coefficient, responsibility coefficient, and correlative coefficient, the industrial mutual relation degree and indurstrial effective degree are analyzed; the leading industry cluster in manufacturing industry of Zhejiang are illustrated. Hopefully, the result could provide the suggestion of decision making for constructing base of advanced manufacturing industry.