Based on the development background of flexibility theory and environmental dynamism, firstly the meaning of introducing flexibility to R&D-Marketing interface management is exploited, and the R&D-Marketing interface management flexibility in its connotation and capability formation are analyzed. Sixteen dimensions for the construction of a firm’s R&D-Marketing interface management flexibility are proposed from eight aspects, that is, structure flexibility, method flexibility, coordinated flexibility, information flexibility, talented person flexibility, decision-making flexibility, cultural flexibility, and strategic flexibility. And the conceptual model of R&D-Marketing interface management flexibility and its functional mechanism are designed and described.