Traditional economics regards regional invention system as a input-output system. The analysis on the efficiency of regional invention emphasizes the efficiency of resources allocation by market mechanism with static equilibrium. Based on the network and its effect of regional invention, this article defines the efficiency of regional invention as dual efficiency with market efficiency and overrun efficiency. With the variable "overrun rate", the authors analyze the dynamic and Parito-optimal "area equilibrium". Finally, the article argues two patterns of improving efficiency including the original efficiency and later-coming one. So the study on the efficiency of regional invention is based on "economy-technology-society-institution".