Based on the hermeneutics process of organizational environment, an integrated model is built. The mechanism of how the organizational knowledge sharing atmosphere influence management innovation is analyzed. The mediation effect of employees’ advice behavior among them and employee self-efficacy’s Moderated Mediation effect are explored. Hypothesis testing based on 301 samples of questionnaire data shows the following: (1) Organizational knowledge sharing atmosphere has significant positive influence on employees’ advice behavior and organizational management innovation; (2) Employees’ advice behavior play a partial mediation role between organizational knowledge sharing atmosphere and management innovation; (3) Employees’ self-efficacy has mediate effect between employees’ promotive advice behavior and enterprise management innovation, and also positively moderate the mediation effect of promotive advice behavior between organizational knowledge sharing atmosphere and enterprise management innovation. But the employees’ prohibitive advice behavior has no significant mediate effect between organizational knowledge sharing atmosphere and enterprise management innovation.