With the intensification of global competition in S&T，there are a lot of breakpoints，blocking points and pain points in China's industrial chain，and the problem of low domestic substitution rate of key links is becoming increasingly prominent. It has become a topic of common concern in both academia and practice how to promote the SRDI enterprises with "unique skills" in the segmentation field to embed quickly into the industrial chain and realize their high-quality growth while empowering the industrial chain. Based on the theories of resource orchestration and enterprise growth，and from the perspective of two-way empowerment of the industry chain，this paper made a dual case study of two SRDI enterprises，and used the grounded theory and Nvivo software to encode the case data，aiming at exploring the internal mechanism of spiral high-quality growth of the SRDI enterprises. The research showed that the process of high-quality growth of SRDI enterprises includes three stages： precise positioning，high coupling and related expansion. In each stage，the complementing chain mechanism and strengthening chain mechanism co-evolve from the perspective of industrial chain empowerment，forming a spiral high-quality growth path that rises both horizontally and vertically，and they are interlocking link by link and progressing step by step. In order to achieve high-quality growth in terms of both "quality" and "quantity"，enterprises need to deploy all dimensions of resource orchestration at each stage. Generally speaking，the importance of resource structuring is very high at all stages，and the importance of turning resources into capability and resource leveraging is gradually improved with the evolution of stages. This paper has not only deepened theoretically the research on the high-quality growth of enterprises in the context of China，but also considered the relationship between complementing chain mechanism and strengthening chain mechanism，and expanded the applicable context and boundary of industrial chain empowerment in the new situation. The research conclusion will have certain reference value for the SRDI enterprises to play a key role in the industrial chain.