Abstract: The current literatures stress on the nature of actors and the interaction between them as an important aspect of regional innovation system. The meaningful operations of the accessibility concept in the innovation process is provided.It is a strong case for the hypothesis that there is a close link between regional accessibility,technological diffusion and the performance of regional innovation systems.A discussion of the type of opportunities relevant to have accessibility for different regions is also contained.

Key words: accessibility, central region, peripheral region, regional innovation system