Abstract:     Knowledge is an important resource in organizations. Resource-based view holds that knowledge is rooted in the culture, routines, system and many other aspects of enterprises, so the effective use of resources affects the innovation of the enterprise, and it can also bring sustainable competitive advantages to the enterprises. Innovation is the result of the interaction between a variety of heterogeneous resources, so alliance cooperation has become an important way to obtain innovation resources, and it may bring unexpected harvests——spillover resources that are difficult to identify and constantly permeate. But companies will face a risky option in the process of innovation cooperation: to use fewer but fully controlled resources, or to access a wider range of resources under limited control.In this paper, 138 valid questionnaires were collected from the biopharmaceutical, electronic information and high-end manufacturing industries in Hefei. Based on knowledge management theory and innovation theory, this paper proposes the concept of R&D boundary permeability from the perspective of the spillover resources that are difficult to clarify and constantly permeate in the R&D alliance, and it systematically analyzes the mechanism of R&D boundary permeability and replication of routines on enterprise innovation.The results show that there is an inverted U-shaped relationship between R&D boundary permeability and firm radical innovation, but the inverted U-shaped relationship between R&D boundary permeability and firm incremental innovation is not obvious. Replication of routines strengthens the inverted U-shaped relationship between R&D boundary permeability and firm radical innovation. It also found that replication of routines is a process of consolidating the relationship with other enterprises, which can strengthen the trust between enterprises, promote the resources flow between different enterprises, promote the enterprise incremental innovation. Thus, R&D boundary permeability and incremental innovation also has an inverted U-shaped relationship.The research results fill the gap of domestic R&D boundary permeability. Permeability is one of the key issues in early R&D boundary decision, so it has an important impact on the innovation capability of enterprises. However, scholars mostly focus on the relationship between network conventions and dual innovation, while ignoring the relationship between the R&D boundary permeability and dual innovation. Based on a review of the literature, this paper clarifies the concept of R&D boundary permeability, establishes the relationship between boundary permeability and firm innovation, and attempts to explore the moderating effect of replication of routines on the mechanism of boundary permeability on innovation capability.For the enterprises in the alliance network, the research results are helpful to the improvement of their dual innovation ability. Firstly, it is proved that moderate boundary permeability is the most beneficial to promote the improvement of innovation ability of enterprises. Secondly, according to different types of innovation activities, the selection of conventional or flexible replication of routines is conducive to the coordination management and resource acquisition and utilization in innovation activities, which can further promote the innovation of enterprises.The research conclusion also has the important enlightenment to the enterprise innovation practice. The modern era is highly open, and knowledge flows quickly. More than ever, leaders need to be open minded and inclusive. Enterprises should take the initiative to learn from excellent enterprises, maintain a good relationship and strengthen communication with excellent enterprise partners, effectively use organizational routines, promote the heterogeneous knowledge flow between different organizations, and provide guarantee for the improvement of innovation ability.

Key words: R&D boundary permeability, incremental innovation, radical innovation, replication of routines