Abstract:    At present, enterprises are facing a critical period of technological transformation in China. Complex and changeable policy situation, highly volatile market environment and rapid iterative technical structure lead to the loss of competitiveness on the part of many enterprises. Only by changing according to the situation, conforming to the development trend and improving the radical innovation capability, can enterprises deal with the uncertain environment and obtain sustainable competitive advantage. Science and technology innovation enterprises are typical organizations with strong demand for radical innovation. Whether they can quickly improve the radical innovation capability is related to whether China has the leading power of core technology in specific fields and whether it can be invincible in the fierce competitive situation. However, the diversified characteristics of the innovation activities of science and innovation enterprises, such as the specific skill demand, the time limit of problem solving, the variability of innovation situation and the fuzziness of solution path, make enterprises always be troubled by resource constraints and path dependence in process of radical innovation. This poses a severe challenge for science and innovation enterprises to improve their radical innovation capability. To this end, it is an important issue to explore how science and innovation enterprises break resource constraints and path dependence, thereby improving the radical innovation capability.
   To address the above problems, according to the theoretical sampling principle, this study selects HB biomedical enterprises as the research object. First of all, as the first domestic scientific and technological innovation enterprise focusing on the R&D of allergen diagnosis technology, it has created the domestic allergen diagnosis market and experienced the whole process of radical innovation. Second, in the process of innovation and development, the enterprise faced the problems of path dependence and resource constraints, and presents different resource constraints in different development stages. However, via good resource orchestration strategy, it broke the resource curse and resource constraints. Finally, in the field of autoimmune diagnosis, HB attaches great importance to the R&D of cutting-edge technologies. It is the first enterprise in China to span the technology platform from the mainstream second-generation backward technology to the internationally leading fourth-generation technology.
    Based on the interview data of the HB, this study adopts an exploratory case analysis method, based on the theoretical logic of "cognition-resource-capability", to analyze how science and technology innovation companies break the resource curse and path dependence, thereby achieving radical innovation capabilities from the perspective of resource orchestration. The study found that in the incremental innovation stage, the market-leading oriented innovation mission urges firms to adopt resource patching strategies under resource scarce situations to provide information support for radical innovation capability that focus on changing the market situation. At the stage of moderate innovation, the innovation mission oriented at localization of products urges companies to adopt resource exploration strategies under resource-constrained situations, and supplies product resources for radical innovation capability centered on improving industry standards. In the fundamental innovation stage, the innovation mission oriented at technological autonomy in the context of resource extension prompts companies to adopt resource leveraging strategies, and provides technical conditions for radical innovation capabilities with the mastery of key technologies.
   This study contributes to the literature in three ways. First, this study clarifies the formation mechanism of the innovation mission of science and innovation enterprises, which not only effectively complements the current organizational mission research horizontally, extends its influence mechanism research, but also expands the situational conditions of the organizational mission research vertically, and defines the specific connotation and causes of the innovation mission in different situations. Second, this study reveals that the innovation mission is the source power of the radical innovation capability, which effectively complements the theoretical gap of the formation power of the current radical innovation capability, helps to promote the academic discussion on the innovation management theory in the context of innovation mission driven, and also deepens the interpretation of the dynamic innovation situation from the perspective of the internal evolution. Finally, from the perspective of resource orchestration strategy, this study reveals how innovation missions in different innovation stages drive enterprises to achieve radical innovation capability, which promotes the research of "resource constraint situation" to expand from general organizational results to radical innovation capability with discontinuity and knowledge frontier.

Key words:  radical innovation capability, innovation mission, resource orchestration, science and technology innovation enterprise