信息化手段和交通便利的结合揭示了电商运营模式的虚实结合本质，综合运用机制分析、BP神经网络、空间计量经济方法，探寻电商运营模式对区域高技术产业创新产出的影响及对空间创新溢出效应的作用。研究发现，我国区域高技术产业创新产出存在显著增强的正向空间自相关；信息化、交通便利度与区域创新间呈指数函数关系，两者的完美结合显著增强区域创新发展的空间溢出效应。其中，信息化对区域高技术产业创新呈现显著增强且稳健的促进趋势，显著增强创新发展的空间溢出效应；交通便利度却呈现显著减弱且不稳健的促进趋势，对创新发展的空间溢出效应作用不显著。提出从顶层设计加强区域一体化建设及监管，注重技术经纪人、专家库的培养与使用，以推动区域创新发展。

The perfect combination of information and convenient transportation reveals an essential feature of the e-commerce operation modes, that is the combination of virtual and reality. Based on this situation, the paper synthetically uses the research methods of mechanism analysis, BP neural network and spatial panel econometric to explore the effect on regional innovation performance and spatial spillover under e-commerce operation modes. The empirical results indicate that positive spatial autocorrelation was significantly and strengthened in regional innovation of high-tech industry. Second, both informational and convenient transportation showed an exponent function relationship with regional innovation. And the perfect combination of information and convenient transportation improved spatial spillover effect on regional innovation significantly. Third, the higher informational development level improved regional innovation development more significantly and strengthened, the effect is steady and increasing the spatial spillover on regional innovation greatly. Fourth, convenient transportation degree improved regional innovation development significantly and decreased, the effect is unstable and can’t improve the spatial spillover significantly. At the end, some suggestions were given to improve regional innovation development level from the angle of conceptual design, such as strengthen the intensity of supervision and construction in the regional integration process, emphasize the training and using of talents like technology broker and expert in database.