本文从投入-产出的角度对中国各地区大中型工业企业技术创新的差异化进行研究。首先利用鸿沟系数从总体上分析中国各地区大中型工业企业的新产品产值、科技活动经费支出、科学家和工程师人数存在的差异，然后应用面板数据模型对30个省市大中型工业企业的技术创新投入对产出的结构影响进行深入分析，找出它们之间的结构差异并说明其存在的原因，为各地提升大中型工业企业技术创新能力提供一些具有针对性的建议。

    The regional differentiation of Middle and Large sized Euterprise(MLE) technological innovation in China is researched form the angel of input-output. Firstly, wide gap coefficient is applied to analyze the regional differentiation of MLE on the industrial output value of new products, expenditures of technological activities, and the number of scientists and engineers in China as a whole. Then, using panel data, the structural influence of input on output about 30 provincial medium-sized and large-sized enterprises’ technological innovation is thoroughly analyzed, the structural differentiation is found out and the cause is explained. In conclusion, some pertinent measures to improve MLE technological innovation ability for each province are put forward.