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新生代创新药企的创新跃迁机制研究——多案例的探索性分析
Research on the innovation transition mechanism of the new-generation of innovative pharmaceutical companies: An exploratory analysis of multiple cases
新生代创新药企实现创新跃迁,是突破“卡脖子”关键核心技术、锻造生物医药领域“国之重器”的重要实践,对于保障人民生命健康、维护国家公共卫生安全具有重要意义。然而,鲜有学者对此新现象展开研究。由此,本文基于IOLL理论运用多案例研究方法,对百济神州、信达生物、君实生物三家新生代创新药企的创新跃迁机制进行系统性探索。研究发现:(1)新生代创新药企依托知识-战略双高位,形成了基于“人才与政策”双杠杆驱动的全球资源编排机制,以加速技术积累。(2)新生代创新药企通过双螺旋持续进化学习机制,体现个体与组织的双向知识赋能是复杂技术突破的持续引擎。(3)新生代创新药企通过资源-学习嵌套“双螺旋”组合机制,呈现了“技术激进”“生态整合”“敏捷聚焦”三种不同特色的创新跃迁路径。本文打开了后发经济体中新生代企业如何在熊彼特-市场Ⅱ型的产业领域实现技术跃迁的黑箱,也为基于科学的企业重构知识以实现高质量发展提供理论与实践参考。
The innovation transition by the new-generation of innovative pharmaceutical companies represents a critical practice in breaking through key core technologies that cause bottlenecks and forging "pillars of a great power" in the biomedicine field. It is of great significance for safeguarding public health and national health security. However, few scholars have conducted research on this emerging phenomenon. Based on the IOLL theory, this paper employed a multiple-case research approach to systematically explore the innovation transition mechanisms of three new-generation of innovative pharmaceutical companies: BeOne Medicines, Innovent Biologics, and Shanghai Junshi Biosciences. The findings revealed that: (1) These companies leverage a dual advantage in knowledge and strategy to form a global resource orchestration mechanism, driven by the dual levers of "talent and policy", thereby accelerating technological accumulation. (2) Through a double helix continuous learning mechanism, it was demonstrated that bidirectional knowledge empowerment between individuals and organizations serves as a sustained engine for breakthroughs in complex technologies. (3) Through a nested "double-helix" combination mechanism of resource and learning, these companies exhibit three distinct innovation transition paths: technological radicalism, ecosystem integration and agile focus. This paper has unraveled the black box of how new generation enterprises in latecomer economies achieve technological transition in Schumpeter Mark II industries. It will also offer some theoretical and practical insights into how science-based firms can restructure their knowledge base to achieve high-quality development.
新生代创新药企 / 创新跃迁 / “高举高打”战略 / 多元动态杠杆 / 双螺旋持续学习
next-generation of innovative pharmaceutical company / innovation transition / strategy for "output of highly oriented products with intensified resources input" / multi-dimensional dynamic leveraging / double helix continuous learning
| [1] |
|
| [2] |
|
| [3] |
|
| [4] |
巴里·沃思. 解药:走进制药新世界[M]. 上海: 上海科技教育出版社, 2022.
|
| [5] |
|
| [6] |
|
| [7] |
|
| [8] |
|
| [9] |
|
| [10] |
|
| [11] |
|
| [12] |
The advancement of artificial intelligence (AI), algorithm optimization and high-throughput experiments has enabled scientists to accelerate the discovery of new chemicals and materials with unprecedented efficiency, resilience and precision. Over the recent years, the so-called autonomous experimentation (AE) systems are featured as key AI innovation to enhance and accelerate research and development (R&D). Also known as self-driving laboratories or materials acceleration platforms, AE systems are digital platforms capable of running a large number of experiments autonomously. Those systems are rapidly impacting biomedical research and clinical innovation, in areas such as drug discovery, nanomedicine, precision oncology, and others. As it is expected that AE will impact healthcare innovation from local to global levels, its implications for science and technology in emerging economies should be examined. By examining the increasing relevance of AE in contemporary R&D activities, this article aims to explore the advancement of artificial intelligence in biomedical research and health innovation, highlighting its implications, challenges and opportunities in emerging economies. AE presents an opportunity for stakeholders from emerging economies to co-produce the global knowledge landscape of AI in health. However, asymmetries in R&D capabilities should be acknowledged since emerging economies suffers from inadequacies and discontinuities in resources and funding. The establishment of decentralized AE infrastructures could support stakeholders to overcome local restrictions and opens venues for more culturally diverse, equitable, and trustworthy development of AI in health-related R&D through meaningful partnerships and engagement. Collaborations with innovators from emerging economies could facilitate anticipation of fiscal pressures in science and technology policies, obsolescence of knowledge infrastructures, ethical and regulatory policy lag, and other issues present in the Global South. Also, improving cultural and geographical representativeness of AE contributes to foster the diffusion and acceptance of AI in health-related R&D worldwide. Institutional preparedness is critical and could enable stakeholders to navigate opportunities of AI in biomedical research and health innovation in the coming years.© 2024. The Author(s).
|
| [13] |
|
| [14] |
刘斌, 江承鑫. “两票制”改革能促进制药企业创新吗[J]. 南开管理评论, 2022, 25(5):54-66.
|
| [15] |
刘晓婷, 吕豪. 从被动支付到战略购买:药品集采对医药企业的影响研究[J/OL]. 南开管理评论,1-23[2025-03-15]. https://link.cnki.net/urlid/12.1288.F.20240611.1026.002.
|
| [16] |
余义勇, 杨忠. 动态情境下企业如何克服组织惰性以实现持续成长?:基于“情境—认知—行动”分析框架[J]. 管理世界, 2022, 38(12):159-177.
|
| [17] |
加里·P.皮萨诺. 科学的生意:生物技术公司如何赚到钱[M].袁源译. 北京: 人民邮电出版社, 2024.
|
| [18] |
孔令辉, 戈乾玮, 邵黎明. 展望2023:聚焦开放、合作与质量,提升创新药物的价值[J]. 药学进展, 2023, 47(3):235-240.
|
| [19] |
|
| [20] |
|
| [21] |
|
| [22] |
许晖, 刘田田, 单宇. 重构资源连接:中国跨国企业如何打破海外技术封锁[J]. 南开管理评论, 2022, 25(6):17-30.
|
| [23] |
The purpose of this study was to explore what agile learning strategies businesses need to develop agile core competencies to respond to the uncertainty of the rapidly changing business environment and sustain their competitive advantage. Technology advances and unexpected crises have created an ever-changing environment in which traditional static corporate training methods have failed to continuously provide employees with the ability to listen to and interpret the rapid changes and respond accordingly.
|
| [24] |
李梦柯, 王芳. 产业创新的科学知识特征对中国技术追赶的影响[J]. 科研管理, 2024, 45 (3):10-19.
|
| [25] |
李根. 经济赶超的熊彼特分析:知识、路径创新和中等收入陷阱[M]. 北京: 清华大学出版社, 2016.
|
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|
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